Natural-born killers

There's a spot of good news in Lyme research this week. Scientists trying to ferret out the role of NK (natural killer) T cells in white blood cells know that dysfunctional or deficient NK T cells seem to lead to autoimmune diseases, such as diabetes, cancer and rheumatoid arthritis -- the kind that plagues the knees of many chronic Lyme sufferers. It seems that these natural-born killer T cells play a big part in helping to clear out bacterial infection. Read on:

RESEARCHERS FROM LA JOLLA INSTITUTE AND ALBANY MEDICAL COLLEGE IDENTIFY CELL GROUP KEY TO LYME DISEASE ARTHRITIS

Research Shows Important Role of NK T cells in Fighting Lyme Disease


SAN DIEGO – (December 3, 2008) A research team led by the La Jolla Institute for Allergy & Immunology and Albany Medical College has illuminated the important role of natural killer (NK) T cells in Lyme disease, demonstrating that the once little understood white blood cells are central to clearing the bacterial infection and reducing the intensity and duration of arthritis associated with Lyme disease.

Click here for the full press release.
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Obstacles to killing the bug

Eva Sapi, Ph.D., who teaches molecular biology for graduate students and does Lyme disease research at the University of New Haven, Connecticut, has one goal. "To kill the bug," she says. "And not in ten years, not even in six months, but soon!" She and her team of medical researchers are intent on figuring out why the Borrelia burgdorferi bacteria, the bug that causes Lyme disease, is so difficult to eradicate.

Lyme disease cases are increasing, and Sapi says she fears this year will be a bad one for ticks, and stresses the importance of prevention. Field research conducted this spring has yielded a disturbing find in her region, she says. The number of ticks carrying the infectious Borrelia bacteria has increased to 60%, up from previous years' 20-30%. She says one possible explanation for the increase could be changing temperatures. Recent mild winters may not have not dropped temperatures sufficiently long enough or frigid enough to kill the ticks.

Sapi is frustrated by the political controversy surrounding Lyme, saying that in her previous research into cancer, such obstacles were not a problem. Unnecessarily harsh criticism of her scientific findings having to do with the Borrelia bacteria has limited the number of publications where her research can be reviewed. However, significant support is increasing from other areas. Grants offered to ILADS from the Turn the Corner Foundation are currently helping fund Sapi's department at University of New Haven for research projects that hopefully, ultimately will help her reach her goal. And soon.

Dr. Sapi spoke with us on April 27, 2008. Members, please keep an eye out for our conversation about her research, to be posted soon to the Lyme Expert Audio Interview page.
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